Nephrology News

Newest Data Shows Childhood Obesity Continues to Increase

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Despite reports in recent years suggesting childhood obesity could be reaching a plateau in some groups, the big picture on obesity rates for children ages 2 to 19 remains unfavorable, according to a new analysis from Duke Health researchers.
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Children With CKD Have Lower IQs

One possible explanation is that increased plasma levels of uremic solutes resulting from kidney disease may impair synaptic development.
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Copeptin Predicts Kidney Diseases

Elevated plasma levels of copeptin, a measure of vasopressin, are associated with an increased risk for chronic kidney disease and other kidney diseases.
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CKD-MBD Guideline Synopsis Issued

Panel focuses on diagnosing and testing of CKD-MBD and treatment of the CKD-MBD that emphasizes decreasing phosphate, maintaining calcium, and addressing elevated PTH in adults with CKD stage G3a to G5.
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Working Nights May Raise Diabetes Risk

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Night-shift work is linked to an increased risk for Type 2 diabetes, a new study has found.

British and American researchers used a large health database to compare diabetes prevalence in 47,286 night-shift workers with that of 224,928 day workers.

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Copeptin Predicts Kidney Diseases

Elevated plasma levels of copeptin, a measure of vasopressin, are associated with an increased risk for chronic kidney disease and other kidney diseases.
Continue reading
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First-line Pazopanib May Improve Outcomes in Advanced RCC

Treatment-naïve patients with advanced clear-cell renal cell carcinoma had significantly longer progression-free survival when treated with pazopanib instead of temsirolimus.
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Resolvin D-1 Limits Kidney Damage After Heart Attacks

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Lingering inflammation after heart attack can lead heart failure. It can also claim another victim -- the kidneys. New research shows that a bioactive compound called resolvin D-1, injected as a therapeutic dose, is able to limit this collateral damage in the kidneys, as tested in an animal model.
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Common blood pressure drug may prevent type 1 diabetes

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Researchers from Colorado and Florida have found that a drug commonly used to control blood pressure could have another use: preventing and treating type 1 diabetes.

Researchers have identified a blood pressure drug that could help to prevent type 1 diabetes.

The new research — co-authored by Dr. Aaron Michels, an associate professor of medicine at the University of Colorado Anschutz Medical Campus in Aurora — will be published in The Journal of Clinical Investigation.

Type 1 diabetes is a condition in which the beta cells of the pancreas are unable to produce enough insulin, which is the hormone that regulates blood sugar levels.

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First-line Pazopanib May Improve Outcomes in Advanced RCC

Treatment-naïve patients with advanced clear-cell renal cell carcinoma had significantly longer progression-free survival when treated with pazopanib instead of temsirolimus.
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Some viruses produce insulin-like hormones that can stimulate human cells -- and have potential to cause disease

Every cell in your body responds to the hormone insulin, and if that process starts to fail, you get diabetes. In an unexpected finding, scientists at Joslin Diabetes Center have identified four viruses that can produce insulin-like hormones that are active on human cells. The discovery brings new possibilities for revealing biological mechanisms that may cause diabetes or cancer.

"Our research may help open up a new field that we might call microbial endocrinology," says Emrah Altindis, PhD, a Joslin research fellow and lead author on a paper in the journal PNAS on the work. "We show that these viral insulin-like peptides can act on human and rodent cells. With the very large number of microbial peptides to which we are exposed, there is a novel window for host-microbe interactions. We hope that studying these processes will help us to better understand the role of microbes in human disease."

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Allograft Nephrectomy Tied to Worse Renal Retransplantation Outcomes

Patients who have a failed renal allograft removed prior to undergoing another kidney transplant may be at increased risk of losing the new allograft, according to a new review.
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Allograft Nephrectomy Tied to Worse Renal Retransplantation Outcomes

Patients who have a failed renal allograft removed prior to undergoing another kidney transplant may be at increased risk of losing the new allograft, according to a new review.
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Anticoagulants Tied With Stroke, Hemorrhage in CKD

Study questions the efficacy and safety of prescribing anticoagulants to older patients with atrial fibrillation and nondialysis chronic kidney disease.
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Coronary Artery Calcification Risk Factors in CKD Identified

Abnormal calcium-phosphate metabolism appears to be an important pathogenic factor in the development of vascular calcification in patients with chronic kidney disease.
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Pulmonary Hypertension Linked With Worse Prognosis in CKD, ESRD

Pulmonary hypertension in patients with any degree of renal insufficiency is associated with elevated risks of cardiovascular events and death.
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Metastatic RCC Treatment With Nivolumab Confirmed Safe, Efficacious

The safety and efficacy of nivolumab for treating metastatic renal cell carcinoma is comparable to that found in the CheckMate 025 trial.
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Axitinib-Pembrolizumab Combo Promising for Advanced RCC

In a phase Ib study, dual therapy with axitinib and pembrolizumab was well tolerated and demonstrated antitumor activity in treatment-naïve patients with advanced renal cell carcinoma.
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Cytoreductive Nephrectomy May Up Survival in Papillary mRCC

Study reveals a 38% decreased risk of death in patients with papillary metastatic renal cell carcinoma who undergo cytoreductive nephrectomy vs those who do not.
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Metastatic Kidney Cancer Outcomes Improved With Combined Therapy

Immunotherapy with atezolizumab plus targeted therapy with bevacizumab improves progression-free survival better than sunitinib in patients with untreated metastatic renal cell carcinoma.
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