Nephrology News

Outcome of extremely low birth weight infants with a history of neonatal acute kidney injury

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Abitbol CL, Seeherunvong W, Galarza MG, Katsoufis C, Francoeur D, Defreitas M, Edwards-Richards A, Master Sankar Raj V, Chandar J, Duara S, Yasin S, Zilleruelo G (2014) Neonatal kidney size and function in preterm infants: what is a true estimate of glomerular filtration rate? J Pediatr 164:1026–1031CrossRefPubMedGoogle Scholar
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When is biopsy-proven TIN not simply TIN? Answers

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Otto EA, Schermer B, Obara T, O’Toole JF, Hiller KS, Mueller AM, Ruf RG, Hoefele J, Beekmann F, Landau D (2003) Mutations in INVS encoding inversin cause nephronophthisis type 2, linking renal cystic disease to the function of primary cilia and left-right axis determination. Nat Genet 34:413–420CrossRefPubMedPubMedCentralGoogle Scholar
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Tolvaptan Offers Sustained Slowing of Renal Function Decline in ADPKD

Open-label extension study confirms disease-modifying effect on eGFR, but not total kidney volume growth.
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AKI Predictors in PE Patients Identified

Chronic kidney disease and anemia are associated with an increased risk for acute kidney injury in patients with pulmonary embolism.
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Children With Diabetic Ketoacidosis at High Risk of AKI

Of the children who developed acute kidney injury, 34.9% had stage 1, 45.3% had stage 2, and 19.8% had stage 3.
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Marathon running may cause short-term kidney injury

According to a new Yale-led study, the physical stress of running a marathon can cause short-term kidney injury. Although kidneys of the examined runners fully recovered within two days post-marathon, the study raises questions concerning potential long-term impacts of this strenuous activity at a time when marathons are increasing in popularity.

The study was published March 28 by the American Journal of Kidney Diseases.

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These five tests better predict heart disease risk

Five simple medical tests together provide a broader and more accurate assessment of heart-disease risk than currently used methods, cardiologists at UT Southwestern Medical Center found.

Combined, results from the five tests -- an EKG, a limited CT scan, and three blood tests -- better predict who will develop heart disease compared with standard strategies that focus on blood pressure, cholesterol, diabetes, and smoking history, researchers reported.

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Topical Gentamicin Superior for Preventing Some PD Infections

Gentamicin cream use was associated with fewer exit-site infections due to gram-negative bacteria.
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Recurrence of Low-Risk RCC Uncommon After Surgery

In a study, the 5-year risk of recurrence was 4.8%, 18.1%, and 46.3% for patients with low-, intermediate-, and high-risk disease.
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Scientists Discover New Class of Anti-Diabetes Compounds That Reduce Liver Glucose Production

Newswise — JUPITER, FL – March 27, 2017 – Scientists may have found a new tool for studying—and maybe even treating—Type 2 diabetes, the form of diabetes considered responsible for close to 95 percent of cases in the United States.

A team of scientists from the Florida campus of The Scripps Research Institute (TSRI), Dana-Farber Cancer Institute, Harvard Medical School and the Yale University School of Medicine, among others, have identified a new class of compounds that reduce production of glucose in the liver. One of these compounds, designed and optimized by TSRI scientists, significantly improves the health of diabetic animal models by reducing glucose levels in the blood, increasing insulin sensitivity and improving glucose balance.

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Diabetes drug could be the first to reverse the disease

A needle for an injection
Type 2 diabetes can require injections of insulin

David Hay Jones/Science Photo Library

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ALP Predicts Mortality in Peritoneal Dialysis Patients With CKD-MBD

Alkaline phosphatase was more strongly linked to mortality compared with other biomarkers of chronic kidney disease-mineral and bone disorder.
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ARE DIALYSIS PATIENTS BEING OVER-SCREENED FOR COLON CANCER?

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Kidney Stone Formation May Differ in MS Patients

Patients with multiple sclerosis are more likely to form calcium phosphate stones and struvite stones.
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Survival of children receiving dialysis varies widely across Europe

All European Union Member States have made commitments towards reducing inequalities in access to health care and in health outcomes. But substantial differences in mortality rates persist in the paediatric renal replacement therapy population across Europe. This is the sad result of a brand new study published in The Lancet this week.

The authors extracted and carefully analyzed patient data from the European Society for Paediatric Nephrology/European Renal Association-European Dialysis and Transplant Association (ESPN/ERA-EDTA) Registry for 32 European countries. In summary, the analysis showed that public health expenditure was inversely associated with mortality risk and explained 67% of the variation in renal replacement therapy mortality rates between countries. Moreover, differences between countries in their ability to treat the youngest patients, who are typically the most complex and costly to treat, were an important driver for poor outcomes.

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Anti-aging peptide recovers fur growth, kidney health in mice

[Mice treated with anti-aging peptide]
An anti-aging therapy could be one step closer; in a new study, researchers reveal how a peptide led to the destruction of cells that play a role in aging, reversing fur loss, kidney damage, and frailty in mice.

The fast-aging mouse on the left shows fur regrowth as a result of peptide treatment. The mouse on the right was untreated.
Image credit: Peter L.J. de Keizer

The research describes how the peptide stops levels of a protein called FOXO4 from increasing in senescent cells, which are cells that lose the ability to replicate and destroy themselves, but which remain metabolically active.

Senescent cells accumulate with age, and studies have shown that they can contribute to the aging process by causing damage to neighboring cells and impairing tissue function.

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Spider venom may offer stroke therapy

Funnel web spider being milked
Image copyright Science Photo Library Image caption Funnel web spiders are milked using a pipette that sucks up their venom

A protein in spider venom may help protect the brain from injury after a stroke, according to research.

Scientists found a single dose of the protein Hi1a worked on lab rats.

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Kidney Stone Formation May Differ in MS Patients

Patients with multiple sclerosis are more likely to form calcium phosphate stones and struvite stones.
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Comparison of the AN69ST membrane versus citrate-enriched dialysate on clotting events during hemodialysis without systemic anticoagulation

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The effect of intra-dialytic exercise on inflammation and blood endotoxin levels

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