Nephrology News

For atrial fibrillation ablation, newer anticoagulant reduces major bleeds

Uninterrupted treatment with dabigatran, a non-vitamin K antagonist oral anticoagulant (NOACs), before, during and after ablation to treat atrial fibrillation significantly reduced the incidence of major bleeding events compared with uninterrupted use of the more established anticoagulant warfarin, according to research presented at the American College of Cardiology's 66th Annual Scientific Session.

The findings offer evidence that dabigatran is a safe and effective alternative to warfarin in the context of atrial fibrillation ablation. The trial showed a 5.3 percent reduction in its primary endpoint, major bleeding events during ablation or in the first two months after the procedure, with major bleeds occurring in 1.6 percent of study participants who received dabigatran and 6.9 percent of patients receiving warfarin.

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Scientists discover new cell structure responsible for unexplained rejections after organ transplant

Drs. Marie-Josée Hébert and Mélanie Dieudé have discovered a new cell structure responsible for previously unexplained rejections following an organ transplant. They have also identified a drug capable of preventing this type of rejection. Recipients of the Award of Excellence in Research - Science Contribution of 2016 at the University of Montreal Hospital Research Center (CRCHUMM), they explain that this discovery could one day revolutionize transplant practice.

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Kidney Cancer Survival Better Among Metformin Users

Patients who used the drug had a 38% lower risk of dying from kidney cancer than non-users, meta-analysis shows.
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Intensive BP Control Does Not Prevent CKD Progression

Blood pressure targets below 130/80 and below 140/90 mm Hg are associated with similar renal outcomes among non-diabetics, meta-analysis shows.
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Statin Timing and Dosage May Improve Heart Surgery Outcomes

Newswise — CHICAGO — Patients on statins should not stop taking the cholesterol-lowering medication before heart surgery—even on the day of surgery, according to an article posted online today in The Annals of Thoracic Surgery. The new research shows that continuation of statins may significantly improve survival following the operation.

“Patients frequently forget to take their pills on the day of surgery, or they’ve been told to stop certain medications,” said Wei Pan, MD, a cardiovascular anesthesiologist at the Texas Heart Institute in Houston. “This study shows that not taking your statin for even 1 day before cardiac surgery may increase your risk of death after surgery. Based on our findings, we would advise patients to continue taking their statin medication all the way up to and including the day of surgery.”

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Intensive BP Control Does Not Prevent CKD Progression

Blood pressure targets below 130/80 and below 140/90 mm Hg are associated with similar renal outcomes among non-diabetics, meta-analysis shows.
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ESRD Renal Recovery Uptick Reported

Use of bioimpedance spectroscopy to assess volume depletion could be a factor, researchers say.
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Kidney Cancer Survival Better Among Metformin Users

Patients who used the drug had a 38% lower risk of dying from kidney cancer than non-users, meta-analysis shows.
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Anemia Indication Sought for Phosphate Binder

Company asks FDA to approve ferric citrate for iron deficiency anemia in patients with non-dialysis dependent chronic kidney disease.
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Early Predialysis Nephrology Care May Prevent CV Events

Patients with early and frequent nephrology visits before dialysis initiation had about a 10% lower risk for major adverse cardiovascular events.
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High folic acid level in pregnancy may decrease high blood pressure in children

A new article published in the American Journal of Hypertension finds that babies born to mothers with cardiometabolic risk factors were less likely to develop high blood pressure if their mothers had higher levels of folate during pregnancy.

Since the late 1980s, the prevalence of childhood elevated blood pressure has increased in the United States, in particular among African Americans. From a life course perspective, childhood high blood pressure can predict higher blood pressure values later in life, and people with higher blood pressure are at greater risk of developing cardiovascular, metabolic and kidney disease and stroke. Research has also shown that maternal cardiometabolic risk factors during pregnancy - including hypertensive disorders, diabetes, and obesity - are associated with higher offspring blood pressure.

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Sodium intake high, rising among people with high blood pressure

Despite recommendations to limit sodium intake to support a heart-healthy lifestyle, daily sodium intake significantly increased in Americans with high blood pressure from 1999-2012, according to a study scheduled for presentation at the American College of Cardiology's 66th Annual Scientific Session.

The study found people with high blood pressure consumed an average of 2,900 milligrams of sodium per day in 1999 and 3,350 milligrams per day in 2012, for an overall average daily sodium intake of 3,100 milligrams during the 14-year study period. That's more than twice the 1,500 milligram daily maximum recommended for people with high blood pressure in dietary guidelines issued by the U.S. Department of Health and Human Services and U.S. Department of Agriculture since 2005.

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SICKLE CELL GENE LINKED TO ELEVATED RISK OF DEVELOPING KIDNEY FAILURE

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New method rescues donor organs to save lives







Researchers have -- for the first time -- maintained a fully functional lung outside the body for several days. They designed the cross-circulation platform that maintained the viability and function of the donor lung and the stability of the recipient over 36-56 hours, used the advanced support system to fully recover the functionality of lungs injured by ischemia and made them suitable for transplant.
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Obesity and Kidney Disease: Hidden Consequences of the Epidemic

World Kidney Day 2017 promotes education on the harmful consequences of obesity and its association with kidney disease, advocating healthy lifestyle and health policy measures that makes preventive behaviors an affordable option.
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Targeted Therapies for Advanced RCC Improve Real-World Survival

Overall survival among patients receiving first-line targeted therapy for advanced renal cell carcinoma increased significantly from 2006 to 2012.
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Advanced CKD Patients May Benefit From Dietary Therapy

Few nephrologists currently prescribe nutritional regimens for their patients approaching the need for renal replacement therapy or who already require it.
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TIMING OF ANTI-DONOR ANTIBODY RESPONSES AFFECTS THE SURVIVAL OF KIDNEY TRANSPLANTS

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Erratum to: Regional citrate anticoagulation for continuous renal replacement therapy in children

Mayerly Prada RicoJaime Fernández SarmientoAna María Rojas VelasquezLuz Stella González ChaparroRicardo Gastelbondo AmayaHernando Mulett HoyosDaniel TibaduizaAna Maria Quintero Gómez
Erratum

DOI: 10.1007/s00467-016-3568-1

Cite this article as: Prada Rico, M., Fernández Sarmiento, J., Rojas Velasquez, A.M. et al. Pediatr Nephrol (2017) 32: 719. doi:10.1007/s00467-016-3568-1

Erratum to: Pediatric Nephrology

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Occurrence of neutrophil dysplasia in the course of severe nephrotic syndrome in a 12-year-old boy on immunosuppressive therapy: Questions

A 12-year-old boy has been treated since he was 9 months old due to severe, recurring, steroid-dependent nephrotic syndrome caused by focal segmental glomerulosclerosis (FSGS). He has been permanently receiving immunosuppressive medications (Table 1).
Table 1

Course of the disease and treatment between 2004 and 2014

The nephrotic syndrome occurring in the patient can be characterized as follows:
1.

The disease developed prior to the boy’s first birthday.

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