Uninterrupted treatment with dabigatran, a non-vitamin K antagonist oral anticoagulant (NOACs), before, during and after ablation to treat atrial fibrillation significantly reduced the incidence of major bleeding events compared with uninterrupted use of the more established anticoagulant warfarin, according to research presented at the American College of Cardiology's 66th Annual Scientific Session.
The findings offer evidence that dabigatran is a safe and effective alternative to warfarin in the context of atrial fibrillation ablation. The trial showed a 5.3 percent reduction in its primary endpoint, major bleeding events during ablation or in the first two months after the procedure, with major bleeds occurring in 1.6 percent of study participants who received dabigatran and 6.9 percent of patients receiving warfarin.